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[Lyme arthritis].

M Caroit

    Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Borrelia burgdorferi infection, or Lyme disease, progresses through distinct phases, potentially causing various neurological, cardiac, and skin lesions. Early diagnosis via the characteristic skin lesion is crucial for effective penicillin or tetracycline treatment, even in late stages.

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    Area of Science:

    • Infectious Diseases
    • Dermatology
    • Neurology

    Background:

    • Lyme disease, caused by the spirochete Borrelia burgdorferi, is prevalent in the US and Europe.
    • The infection evolves through distinct phases, manifesting with varied symptoms over time.
    • Geographical variations exist in the presentation of later-stage Lyme disease.

    Purpose of the Study:

    • To describe the phased evolution of Borrelia burgdorferi infection.
    • To highlight the diagnostic significance of early cutaneous manifestations.
    • To emphasize the role of persistent infection in disease progression and treatment efficacy.

    Main Methods:

    • Clinical observation of disease progression and lesion development.
    • Identification of Borrelia burgdorferi in various disease stages.

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  • Review of treatment outcomes with antibiotics.

    • Main Results:

    • Early phase: chronic migrating erythema (primary lesion).
    • Secondary phase: neurological and cardiac lesions (cardiac more common in US).
    • Tertiary/Late phases: joint, central nervous system, and chronic skin lesions (acrodermatitis) with regional variations.

    Conclusions:

    • Borrelia burgdorferi persistence is implicated in the long-term evolution of Lyme disease.
    • Early diagnosis, particularly of the erythema migrans, is key for timely antibiotic intervention.
    • Penicillin and tetracycline treatments remain effective, even for chronic and late-stage Lyme disease manifestations.