Cardiovascular Involvement in Sjögren's Syndrome

Area of Science:

• Rheumatology
• Cardiology
• Clinical Medicine

Background:

• Sjögren Syndrome (SS) is linked to increased cardiovascular (CV) and cerebrovascular event risk.
• CV events are a significant burden in SS patients, despite not being a primary disease feature.
• CV risk in SS arises from traditional factors and disease-specific mechanisms, including endothelial dysfunction.

Purpose of the Study:

• To evaluate the risk of cardiovascular events in primary Sjögren Syndrome.
• To assess the effect of available treatments on cardiovascular manifestations in SS patients.

Main Methods:

• Systematic review of existing literature.
• Analysis of studies reporting cardiovascular outcomes in primary SS patients.
• Evaluation of treatment data concerning cardiovascular risk in SS.

Main Results:

• Sjögren Syndrome is associated with a higher overall risk of cardiovascular and cerebrovascular events.
• The precise impact of disease-related mechanisms and traditional risk factors on CV events in SS requires further elucidation.
• Data on the specific effects of SS treatments on cardiovascular events remain limited.

Conclusions:

• Cardiovascular risk is a critical consideration in managing Sjögren Syndrome patients.
• Further research is needed to clarify the interplay of factors contributing to CV risk in SS.
• Investigating the efficacy of SS therapies in mitigating cardiovascular events is essential.