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Updated: Sep 21, 2025
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Published on: October 21, 2022
Corneal Endothelial Characteristics in Normal Chinese Han Children and Youngsters: A Study from the Specular
Lilian Xie1, Huilong Fang2, Yuyu Xie3
1The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, Hunan, China 423000.
Objective:
To observe the morphological changes of corneal endothelial cells in healthy Chinese children and youngsters and analyze the sensitive and specificity of the endothelial assessments.
Methods:
14,670 Chinese healthy volunteers enrolled were examined by specular microscopy, and the endothelial descriptive indexes: the central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation in average cell size (CV), the percentage of regular hexagonal cells (hexagonality, HEX), cell size of minimal cell (S min), cell size of maximal cell (S max), average cell size (S avg), and size of standard deviation of cell area (S sd) as well as sex and age were analyzed.
Results:
The average age of this study is 17.36 ± 7.58 (4-30) years. There is no sex predominance: 7,260 male (49.5%) and 7,410 female (50.5%). The mean CCT, ECD, CV, HEX, S min/max, S avg, and S sd are 529.94 ± 31.53 (437-644) μm, 3,051.28 ± 375.49 (2,031-4,074) cells/mm2, 28.34 ± 4.36 (18-40) %, 61.21 ± 10.29 (17-89) %, (147.79 ± 21.94 to 678.29 ± 120.96) μm2, 332.74 ± 44.62 μm2, and 95.02 ± 23.17 μm2, respectively. The CCTs keep consistency. The ECD decreased rate is 1.02%/year. The curve of ECD and hexagonality expresses the same linear tender. The CCT and endothelial evaluation indexes have no sex predominant (p > 0.05); the quantitative indicators: CCT, ECD, and HEX are significant negative associated with age (p = 0.001 or p < 0.001); the variability indexes: the CV, S min, S max, S avg, and S sd are positive correlation (p < 0.001). The coefficients of CCT, HE, and S min are -0.35, -0.59, and 1.17, respectively.
Conclusions:
The ECD decrease rate is 1.02%/year of the normal Chinese Han childhood to the earlier adulthood. The ages 4 to 12, 13 to 20, and 21 to 30 can be named as the childhood, puberty and adulthood from endothelial biologic identity. The HEX is the sensitivity marks for the polymorphisms while the S min is the specificity indicator CVs upon the Topcon Noncon Specular microscopy results.
