Related Experiment Videos
[Familial Mediterranean fever. Study of a Swiss child]
Abstract:
Familial Mediterranean fever (FMF) has been observed in a Swiss child without ethnic predisposition. The case is analyzed and the current literature briefly reviewed. Recurrent attacks of fever, accompanied by abdominal pain, colic and arthritic symptoms, and often by pleuritic pain and a transitory skin rash, are the hallmarks of FMF, which is predominantly seen in ethnic groups of the Mediterranean area, notably Sephardic Jews, Turks and Armenians. However, it rarely occurs among individuals without an ethnic predisposition. Its most ominous manifestation is amyloidosis, which leads to chronic renal failure within a matter of years. Thanks to colchicine treatment, which is now widely accepted, patients often lead normal lives, and it appears that amyloidosis can be prevented.
Insights
Familial Mediterranean fever (FMF), a rare condition in non-Mediterranean populations, was diagnosed in a Swiss child. Early colchicine treatment can prevent serious complications like kidney failure.
Area of Science:
- Genetics and rare diseases
- Pediatric rheumatology
Background:
- Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
- FMF predominantly affects individuals of Mediterranean descent, including Sephardic Jews, Turks, and Armenians.
- Amyloidosis, leading to chronic renal failure, is a severe complication of untreated FMF.