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Updated: Sep 21, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Arterial Calcification and Its Association With Stroke: Implication of Risk, Prognosis, Treatment Response, and

Xiang Wang1,2, Xinghang Chen1,2, Zhuohui Chen1,2

  • 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Cellular Neuroscience
|May 31, 2022
PubMed

Insights

Vascular calcification (VC), the hardening of arteries due to calcium deposits, is linked to stroke risk and outcomes. This review explores how large artery calcification impacts stroke and potential prevention strategies.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Vascular Biology

Background:

  • Vascular calcification (VC) is a hallmark of vascular aging, involving calcium-phosphate deposition in blood vessels.
  • Intimal calcification relates to atherosclerosis and plaque stability, while medial calcification causes arterial stiffening.
  • Arterial calcifications, including intracranial, coronary, and carotid arteries, are increasingly associated with stroke risk and prognosis.

Purpose of the Study:

  • To review recent findings on the association between large artery calcification and stroke.
  • To explore the impact of VC on stroke risk, prognosis, treatment response, and prevention.
  • To discuss potential underlying mechanisms linking large artery calcification and stroke.

Main Methods:

  • Literature review of recently published studies.
  • Synthesis of evidence on vascular calcification and stroke.
  • Analysis of proposed mechanisms connecting large artery calcification and stroke outcomes.

Main Results:

  • Large artery calcification is associated with increased stroke risk.
  • VC impacts stroke prognosis and influences treatment effectiveness.
  • Calcifications in large arteries may contribute to cerebral hemodynamic impairment and small vessel disease.

Conclusions:

  • Vascular calcification is a significant factor in stroke.
  • Understanding the link between large artery calcification and stroke is crucial for prevention and management.
  • Further research into the mechanisms of VC in stroke is warranted.

Keywords:
arterial calcificationcalcification scoring methodcomputed tomographyradiographystroke

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