HPV Associated Squamous Cell Carcinoma in the Rectal Tonsil.

Area of Science:

• Gastrointestinal Pathology
• Oncology
• Human Papillomavirus (HPV) Research

Background:

• Mucosa-associated lymphoid tissue is present in the gastrointestinal tract, including the rectum.
• A rare nodular proliferation of submucosal lymphoid tissue in the rectum is termed rectal tonsil.

Observation:

• A patient presented with a polypoid lesion in the rectum.
• The lesion was identified as a human papillomavirus (HPV)-associated squamous cell carcinoma of the rectal tonsil.

Findings:

• This case represents an extremely rare occurrence of HPV-associated squamous cell carcinoma within a rectal tonsil.
• The neoplasm presented clinically as a rectal polyp.

Implications:

• Highlights the importance of recognizing HPV-associated malignancies in extranodal lymphoid tissues.
• Emphasizes the need for precise nomenclature based on the tumor's pathogenesis for accurate diagnosis and reporting.
• Contributes to the understanding of rare rectal neoplasms and their association with HPV.