Senescence-mediated anticancer effects of quercetin
Serpil Özsoy Gökbilen1, Eda Becer2, Hafize Seda Vatansever3
1Faculty of Health Sciences, Department of Nutrition and Dietetics, Near East University, Nicosia, Cyprus..
Nutrition Research (New York, N.Y.)
|May 31, 2022
Summary
Cellular senescence contributes to aging and cancer. Senolytics, like the natural compound quercetin, selectively eliminate senescent cells, showing promise in preventing and treating cancer.
Area of Science:
- Gerontology
- Oncology
- Molecular Biology
Background:
- Cellular senescence is a critical factor in aging and age-related diseases.
- Senescence acts as an antitumor mechanism but can lead to cancer recurrence due to apoptosis resistance.
- Senolytics are a novel drug class designed to eliminate senescent cells.
Purpose of the Study:
- To review the role of cellular senescence in cancer development.
- To examine the senolytic and anti-cancer effects of quercetin.
- To explore quercetin's potential as a pro-apoptotic and anti-proliferative agent.
Main Methods:
- Literature review on cellular senescence, carcinogenesis, and senolytics.
- Analysis of preclinical and early-phase clinical data on quercetin's efficacy.
- Examination of quercetin's antioxidant and pro-apoptotic properties.
Main Results:
- Quercetin demonstrates senolytic activity, selectively eliminating senescent cells.
- Preclinical data suggest quercetin can prevent or alleviate cancer formation.
- Quercetin exhibits antioxidant and pro-apoptotic effects relevant to cancer suppression.
Conclusions:
- Cellular senescence is a significant factor in cancer initiation and progression.
- Quercetin shows potential as a senolytic agent for cancer therapy.
- Further research into quercetin's role in cancer prevention and treatment is warranted.
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