Related Experiment Video
Updated: Sep 21, 2025
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
Published on: December 16, 2022
Relationship between baseline haemoglobin content and poststroke cognitive impairment
Weili Jia1, Qian Jia2, Yuesong Pan3
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Objective:
This study aims to explore the relationship between baseline haemoglobin (Hb) content and poststroke cognitive impairment (PSCI) within 3 months following an acute ischaemic stroke or transient ischaemic attack (TIA).
Methods:
Data are from a national multicentre prospective study that recruited patients with acute ischaemic stroke/TIA within 7 days. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCA). PSCI was defined as a MoCA score ≤ 23 within 3 months after stroke onset. The relationship between Hb content and PSCI was assessed by a multiple regression model after adjusting for other potential confounders. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
Results:
A total of 2240 patients were included in this study. The average age was 60.96 ± 10.76 years old, and 784 (35.00%) patients experienced cognitive impairment within 3 months after acute ischaemic stroke/TIA. Patients with anaemia had a significantly lower MoCA score than those without anaemia at the 3-month follow-up (22.53 ± 5.56 versus 23.68 ± 4.77, P = 0.001). In a multiple regression analysis after adjusting for other confounders, patients with high Hb content were associated with a lower risk of PSCI than those with anaemia (OR 0.64, 95% CI 0.43-0.94, P = 0.02). Hb content was negatively related to the risk of PSCI within 3 months after stroke onset (OR 0.93, 95% CI 0.85-0.94 per 10 g/L increment, P = 0.04).
Conclusion:
Baseline Hb content was an independent protective predictor for PSCI in patients with acute ischaemic stroke/TIA.
