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Structural insights into ORF10 recognition by ZYG11B.

Bing Zhang1, Yao Li1, Qiqi Feng1

  • 1Department of Biochemistry and Molecular Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.

Biochemical and Biophysical Research Communications
|May 31, 2022
PubMed
Summary

Researchers elucidated how the SARS-CoV-2 ORF10 protein N-terminus interacts with ZYG11B, a key component of the CRL2 ubiquitin ligase. This finding advances understanding of viral protein recognition and may aid in developing new COVID-19 therapies.

Keywords:
Crystal structureCullin-RING E3 ligaseORF10ZYG11B

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