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Phylogenetic analysis of porcine circovirus 3 circulating in Canadian pigs
Maodong Zhang1,2, Chao Chun Liu3, Yanyun Huang1,2
1Prairie Diagnostic Services Inc., Saskatoon, Saskatchewan, Canada.
Introduction:
Porcine circovirus 3 (PCV3) has been detected in pigs worldwide and associated with several clinical signs.
Methods:
To investigate the genetic diversity of PCV3 strains circulating in Canada, 44 PCV3 positive samples from Saskatchewan (2/44), Manitoba (2/44), Quebec (4/44), Alberta (11/44) and Ontario (25/44) submitted to diagnostic laboratories in Canada between 2019 and 2021 were sequenced and analyzed.
Results:
Phylogenetic analysis of capsid genes showed that all of the 44 Canadian strains classified into PCV3a and segregated into seven lineages with common amino acid changes observed at A24V, R27K, N56D, T77S, Q98R, L150I (F) and R168K positions.
Conclusion:
Future studies are required to determine whether the polymorphisms in capsid proteins, as revealed in this study, could be associated with differences in the pathogenicity or antigenicity of PCV3 strains. This is the first phylogenetic analysis of PCV3 strains among different provinces in Canada.
