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The oral microbiome, nitric oxide and exercise performance.

Nathan S Bryan1, Mia C Burleigh2, Chris Easton2

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Summary
This summary is machine-generated.

The oral microbiome impacts nitric oxide (NO) production, affecting blood pressure and oral health. Disrupting oral bacteria reduces NO, while promoting nitrate-reducing bacteria may enhance it, though effects on exercise performance require further study.

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Area of Science:

  • Microbiology
  • Physiology
  • Human Health

Background:

  • The human microbiome plays a vital role in host metabolism.
  • Oral bacteria are crucial for converting nitrate to nitrite, a precursor to nitric oxide (NO).
  • Nitric oxide is essential for cardiovascular homeostasis and exercise responses.

Purpose of the Study:

  • To review the influence of oral microbiome diversity and plasticity on NO bioavailability.
  • To examine the impact of oral microbiota alterations on physiological outcomes.
  • To explore the relationship between the oral microbiome, NO, and exercise performance.

Main Methods:

  • Narrative review of existing research.
  • Analysis of studies on oral microbiota dysbiosis and disruption.
  • Examination of evidence for dietary and probiotic interventions.

Main Results:

  • Dysbiosis or disruption of the oral microbiota suppresses NO production via the nitrate-nitrite-NO pathway, negatively impacting blood pressure.
  • Preliminary evidence suggests that increasing nitrate-reducing bacteria can enhance NO production and improve oral health markers.
  • The impact of purposefully altering the oral microbiome on exercise performance remains to be established.

Conclusions:

  • The oral microbiome significantly influences NO bioavailability, with implications for cardiovascular health and oral well-being.
  • Interventions targeting the oral microbiome may offer therapeutic potential for managing blood pressure and improving oral health.
  • Further research is needed to determine the effects of oral microbiome modulation on acute exercise responses and training adaptations.