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Updated: Sep 21, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

COVID-19 and Pregnancy.

Sonja A Rasmussen¹, Denise J Jamieson²

¹Department of Pediatrics, University of Florida College of Medicine, 1600 Archer Road, Box 100296, Gainesville, Florida, 32610; Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL, USA; Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, FL, USA.

Infectious Disease Clinics of North America

|May 31, 2022

Summary

This summary is machine-generated.

Pregnant individuals with COVID-19 face higher risks of severe illness and complications. Vaccination during pregnancy is safe and effective, potentially protecting infants, yet uptake remains low, necessitating research into vaccine hesitancy.

Keywords:

COVID-19 Intrauterine transmission Pregnancy Pregnancy complications SARS-CoV-2 SARS-CoV-2 vaccine mRNA vaccine

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Area of Science:

Obstetrics and Gynecology
Infectious Diseases
Immunology

Background:

Pregnancy is a known risk factor for severe COVID-19 outcomes.
While intrauterine SARS-CoV-2 transmission is rare, maternal COVID-19 increases pregnancy complication risks, especially in severe cases.
COVID-19 vaccination in pregnancy is considered safe and effective.

Purpose of the Study:

To review the risks of COVID-19 in pregnancy.
To assess the safety and efficacy of COVID-19 vaccination during pregnancy.
To highlight the need for strategies addressing vaccine hesitancy in pregnant populations.

Main Methods:

Literature review of studies on COVID-19 in pregnancy.
Analysis of data on pregnancy complications associated with SARS-CoV-2 infection.
Examination of evidence regarding maternal and infant benefits of COVID-19 vaccination.

Main Results:

COVID-19 during pregnancy elevates risks for severe maternal illness and pregnancy complications.
Maternal COVID-19 vaccination generates protective antibodies in umbilical cord blood and breast milk.
Low vaccination rates among pregnant individuals persist despite proven safety and efficacy.

Conclusions:

Pregnant individuals are at increased risk for severe COVID-19.
COVID-19 vaccination during pregnancy offers maternal and potential infant protection.
Addressing vaccine hesitancy is crucial to improve vaccination rates in pregnant populations.