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Association between serum creatinine level within normal range and bone mineral density in adolescents
1Department of Nephrology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, China.
Summary
Higher serum creatinine (SCre) levels in adolescents correlate with increased bone mineral density (BMD). This suggests SCre may serve as a useful biomarker for adolescent bone health.
Area of Science:
- Endocrinology
- Pediatrics
- Bone Metabolism
Background:
- Serum creatinine (SCre) is a stable indicator of skeletal muscle mass.
- Limited evidence exists on the relationship between SCre and bone health.
- Adolescence is a critical period for bone development.
Purpose of the Study:
- To investigate the association between normal serum creatinine levels and bone mineral density (BMD) in adolescents.
- To explore potential links between muscle mass indicators and bone health during adolescence.
Main Methods:
- Analysis of data from 3,395 adolescents (aged 12-19) from the National Health and Nutrition Examination Survey (2011-2018).
- Utilized weighted multiple linear regression to assess SCre and BMD association.
- Employed weighted generalized additive models for nonlinearity analysis.
Main Results:
- Higher SCre levels were positively associated with total and lumbar BMD in adolescents.
- This association was consistent across subgroups stratified by age, gender, and race.
- The positive association was stronger in adolescent boys compared to girls aged 12-15.
Conclusions:
- Elevated SCre levels within the normal range are linked to higher BMD in adolescents.
- SCre may represent a potential biomarker for monitoring bone health in adolescents.
- Further research can elucidate the mechanisms underlying this association.
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