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Engineering the next generation of cell-based therapeutics.
Caleb J Bashor1,2, Isaac B Hilton3,4, Hozefa Bandukwala5,6
1Department of Bioengineering, Rice University, Houston, TX, USA. caleb.bashor@rice.edu.
Nature Reviews. Drug Discovery
|May 31, 2022
Summary
Cell-based therapeutics offer potent treatments for intractable diseases. Advanced engineering approaches are overcoming challenges in cell sourcing, product quality, and scalable manufacturing for wider clinical use.
Area of Science:
- Regenerative Medicine
- Biotechnology
- Therapeutic Development
Background:
- Cell-based therapeutics represent a promising frontier for treating complex diseases.
- Recent successes highlight their potential, yet significant hurdles remain for broad application.
Purpose of the Study:
- To outline the challenges hindering the translation and commercialization of cell-based therapies.
- To highlight innovative engineering strategies addressing these limitations.
Main Methods:
- Review of current challenges in cell source identification, product viability, potency, safety, and manufacturing.
- Exploration of next-generation engineering approaches like genome editing, synthetic biology, and biomaterials.
Main Results:
- Key challenges identified include cell sourcing, product quality control, and scalable manufacturing.
- Next-generation engineering offers solutions for these critical issues.
Conclusions:
- Overcoming manufacturing and product development challenges is crucial for cell therapy advancement.
- Cutting-edge research in engineering is vital for realizing the full potential of cell-based therapeutics.
