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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
2.6K
[Treatment of keloids].
Fabienne Oettgen1, Frank Haubner2
1Klinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, LMU Klinikum, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland. fabienne.oettgen@med.uni-muenchen.de.
HNO
|May 31, 2022
Summary
Keloids are fibroproliferative diseases causing cosmetic and functional issues. Multimodal treatment concepts show promise, particularly for auricular keloids, despite limited evidence due to small studies.
Area of Science:
- Dermatology
- Wound Healing
- Fibroproliferative Diseases
Background:
- Keloids are a common type of fibroproliferative disease.
- They often lead to significant cosmetic and functional impairment, accompanied by symptoms like itching and pain.
- The exact pathogenesis of keloids remains unclear, and current treatments are frequently prolonged and unsatisfactory.
Purpose of the Study:
- To review the current therapeutic options for keloid treatment.
- To highlight the potential of multimodal treatment concepts.
- To assess the effectiveness of these concepts, especially for auricular keloids.
Main Methods:
- Review of existing literature on keloid treatment.
- Analysis of studies focusing on various therapeutic modalities.
- Evaluation of multimodal approaches, particularly in the context of auricular keloids.
Main Results:
- A wide range of treatments exist for keloids, but the evidence base is limited by small study sizes.
- Multimodal treatment strategies appear promising for managing keloids.
- Good results have been observed with multimodal concepts, specifically for auricular keloid cases.
Conclusions:
- Keloid treatment remains challenging due to unclear pathogenesis and limited high-quality evidence.
- Multimodal therapeutic concepts represent a promising avenue for improving keloid management.
- Further research with larger studies is needed to establish definitive treatment guidelines.

