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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Related Experiment Video

Updated: Sep 21, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Dermatofibrosarcoma protuberans with unusual presentation in vulva.

Rina Barrios Barreto1, Liney Mendoza Suarez2, Astrid Del Valle2

  • 1División Ciencias de la Salud, Universidad del Norte, Barranquilla, Colombia.

Medicina
|May 31, 2022
PubMed
Summary

Dermatofibrosarcoma protuberans is a rare vulvar cancer. Targeted therapy with imatinib shows promise for treating this locally aggressive tumor, especially when surgery is not feasible.

Keywords:
cancercollagen type 1 alpha 1 chaindermatofibrosarcomaplatelet-derived growth factor bvulva

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Area of Science:

  • Gynecologic Oncology
  • Dermatopathology
  • Surgical Pathology

Background:

  • Gynecological sarcomas are rare, accounting for 5% of female genital tract neoplasms.
  • Dermatofibrosarcoma protuberans (DFSP) is an infrequent vulvar tumor with fewer than 60 reported cases globally.

Observation:

  • A case of a 54-year-old patient with vulvar DFSP is presented.
  • DFSP is characterized by locally aggressive spindle cell proliferation with high recurrence rates.
  • Histopathology reveals pleomorphism, mitotic figures, and infiltration of dermal and subcutaneous tissues.

Findings:

  • The COL1A1-PDGFB fusion gene, resulting from translocation t(17;22), drives tumor cell proliferation.
  • Surgical excision, including Mohs micrographic surgery, is the primary treatment.
  • Imatinib, a tyrosine kinase inhibitor, is effective for unresectable tumors and recurrences.

Implications:

  • Understanding the molecular basis of DFSP enables targeted therapeutic strategies.
  • Imatinib offers a neoadjuvant or alternative treatment option for vulvar DFSP.
  • This case highlights the importance of considering rare vulvar malignancies and their specific treatments.