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Antibody prophylaxis against Tembusu virus-associated disease
Qiong Li1, Chonglun Feng1, Baolin Yang1
1Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China.
Archives of Virology
|May 31, 2022
Summary
Passive administration of Tembusu virus (TMUV) immune serum protected young Pekin ducks from TMUV disease. Antibodies significantly reduced mortality, tissue damage, and viral load, confirming their protective role against TMUV infection.
Area of Science:
- Veterinary Virology
- Immunology
Background:
- Tembusu virus (TMUV) is known to induce neutralizing antibodies.
- The protective capacity of these antibodies against TMUV-associated disease and viral replication in vivo is not fully understood.
Purpose of the Study:
- To investigate the prophylactic efficacy of TMUV immune serum in a young Pekin duck model.
- To determine the role of antibodies in protection against TMUV infection.
Main Methods:
- Passive administration of TMUV immune serum to 2-day-old Pekin ducklings.
- Subsequent challenge with TMUV.
- Assessment of protection against morbidity, mortality, tissue injury, and viral loads in peripheral and central nervous systems.
Main Results:
- Passive transfer of TMUV immune serum conferred significant protection against TMUV-induced morbidity and mortality.
- Immune serum substantially reduced TMUV-associated tissue damage.
- TMUV levels were significantly decreased in both peripheral and central nervous systems of protected ducklings.
Conclusions:
- Antibodies play a dominant role in controlling Tembusu virus-associated disease.
- Passive immunity via TMUV antibodies is effective in preventing severe outcomes of TMUV infection in young ducks.
