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Role of surfactant protein-D in ocular bacterial infection

Xinzhu Hou1, Xin Zhang1, Zhiyong Zhang2,3

  • 1The Second Affiliated College of Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, People's Republic of China.

International Ophthalmology
|May 31, 2022
PubMed
Abstract

Insights

Surfactant protein D (SP-D) plays a key role in defending against ocular bacterial infections. This immune factor shows potential for diagnosing, predicting, and treating eye infections.

Area of Science:

  • Immunology
  • Ophthalmology
  • Microbiology

Background:

  • Surfactant protein D (SP-D) is an immune factor present in ocular surface tissues.
  • SP-D plays a role in defending against pathogen invasion.

Purpose of the Study:

  • To explain the role of SP-D in various ocular bacterial infections.
  • To identify new prospects for SP-D-mediated immune processes in ocular bacterial infections.
  • To explore SP-D's potential in the diagnosis, prognosis, and treatment of ocular bacterial infections.

Main Methods:

  • A systematic review of articles was conducted.
  • Databases searched included PubMed, Google Scholar, and the Web of Science.
  • Articles focused on SP-D's role in ocular bacterial infections and related diseases.

Main Results:

  • Increased SP-D production in tears and cornea observed in bacterial keratitis (e.g., Staphylococcus aureus, Pseudomonas aeruginosa) and related diseases.
  • SP-D exhibits anti-inflammatory effects and defends against pathogen invasion through mechanisms like opsonization and phagocytosis.
  • SP-D's action involves pathways such as TLR-5, TLR-4, and TLR-2, with further elucidation needed.

Conclusions:

  • SP-D is involved in combating ocular bacterial infections and related diseases via multiple immune mechanisms.
  • SP-D holds promise as a diagnostic biomarker, prognostic predictor, and therapeutic target for ocular bacterial infections.
Keywords:
Bacterial keratitisImmune mechanismOcular bacterial infectionSurfactant protein D

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