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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Sep 21, 2025

Polymer Microarrays for High Throughput Discovery of Biomaterials

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

Programmable and Flexible Fluorochromic Polymer Microarrays for Information Storage.

Hongyan Xia^1,2, Yuguo Ding², Jingjing Gong²

¹State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment, School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, Guangdong 510006, China.

ACS Applied Materials & Interfaces

|May 31, 2022

Summary

This study introduces a new method for information storage using photoresponsive materials. By controlling light, researchers created tunable color and fluorescence for high-density, secure data storage and anti-counterfeiting applications.

Keywords:

Förster resonance energy transfer fluorochromic information storage photoresponsive polymer microarray

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Last Updated: Sep 21, 2025

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Area of Science:

Materials Science
Optics
Chemistry

Background:

Photoresponsive fluorochromic materials offer effective information storage through reversible color and fluorescence changes.
Increasing storage capacity and facilitating data storage are key goals in materials science.

Purpose of the Study:

To develop an optically reconfigurable Förster resonance energy transfer (FRET) process for tunable emissions.
To create programmable FRET systems using photochromic spiropyrans and common fluorophores.
To fabricate flexible microarrays for advanced information storage and anti-counterfeiting.

Main Methods:

Systematic investigation of spiropyran photoisomerization kinetics and composite FRET processes.
Tuning acceptor spiropyran and donor fluorophore ratios and applying light stimuli for programmable FRET.
Inkjet printing (230 ppi) to fabricate flexible microarrays from fluorochromic mixtures.

Main Results:

Achieved tunable emissions by optically reconfiguring the FRET process.
Demonstrated programmable FRET with tunable outputs through ratio tuning and light stimuli.
Successfully fabricated flexible polymer microarrays with dynamic FRET for tunable fluorescence.

Conclusions:

Developed a programmable FRET system for tunable fluorescence in microarrays.
Enabled novel optically readable media for information storage with anti-counterfeiting capabilities.
Advanced high-density, high-security information storage platforms using large-scale flexible polymer microarrays.