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Updated: Sep 21, 2025

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
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ExpressVis: a biologist-oriented interactive web server for exploring multi-omics data.

Xian Liu1,2, Kaikun Xu1, Xin Tao1,3

  • 1State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Nucleic Acids Research
|May 31, 2022
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Summary
This summary is machine-generated.

ExpressVis is a new web server that helps biologists analyze complex multi-omics data. This biologist-oriented platform offers interactive visualization and analysis tools for easier biological insight discovery.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • The increasing volume of multi-omics data presents challenges for biologists lacking advanced programming skills.
  • Effective tools are needed to make complex omics data accessible and interpretable for biological research.

Purpose of the Study:

  • To develop an intuitive, interactive web server, ExpressVis, for biologists to analyze and visualize multi-omics data.
  • To provide a user-friendly platform for integrating various omics datasets and performing key biological analyses.

Main Methods:

  • ExpressVis offers six modules for data preparation, differential expression analysis, clustering, and survival analysis.
  • The platform integrates expression data with protein-protein interaction networks and pathway maps.
  • Results are presented through interactive figures and tables with comprehensive inter- and intra-module operations.

Main Results:

  • ExpressVis successfully re-analyzed a hepatocellular carcinoma dataset, reproducing key findings.
  • The platform demonstrated convenience and effectiveness in multi-omics studies of clinical cohorts.
  • Interactive features facilitate in-depth exploration of complex biological data.

Conclusions:

  • ExpressVis provides a biologist-oriented, easy-to-use solution for exploring multi-omics data.
  • The platform's interactive nature and comprehensive analyses empower researchers to gain biological insights.
  • ExpressVis is freely accessible and requires no login, promoting wider adoption in biomedical research.