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Peritubular Capillaritis in Native Kidney Biopsies
Sulen Sarioglu1, Emel Tekin2, Mehtat Unlu1
1Department of Pathology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
American Journal of Clinical Pathology
|May 31, 2022
Summary
Peritubular capillaritis (PTCitis) is common in native kidney biopsies. Interstitial inflammation, pauci-immune glomerulonephritis, and higher serum creatinine predict PTCitis.
Area of Science:
- Nephrology
- Pathology
Background:
- Peritubular capillaritis (PTCitis) is a finding in kidney biopsies.
- Understanding its frequency and predictors is crucial for diagnosis and management.
Purpose of the Study:
- To determine the frequency of PTCitis in native kidney biopsies.
- To identify demographic and clinicopathologic predictors of PTCitis.
Main Methods:
- 169 consecutive native kidney biopsies were reviewed for PTCitis using Banff Classification criteria.
- Logistic regression analysis was performed to identify predictors of PTCitis.
Main Results:
- PTCitis was present in 53.3% of biopsies.
- Interstitial inflammation, pauci-immune glomerulonephritis, and higher serum creatinine were independent predictors of PTCitis.
- Severe interstitial fibrosis/tubular atrophy was associated with a lower risk of PTCitis.
Conclusions:
- PTCitis is a frequent finding in native kidney biopsies.
- Interstitial inflammation, pauci-immune glomerulonephritis, and elevated serum creatinine are associated with increased risk of PTCitis.
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