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Con: freeze-all for all? One size does not fit all
Lan N Vuong1,2
1Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Human Reproduction (Oxford, England)
|May 31, 2022
Summary
The freeze-all embryo strategy in IVF may reduce OHSS risk but results are inconsistent. A personalized approach is best, as freeze-all is not ideal for all patients undergoing fertility treatments.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization (IVF)
- Embryology
Background:
- Traditionally, in vitro fertilization (IVF) involved fresh embryo transfer.
- A 'freeze-all' strategy, cryopreserving all embryos for later transfer, is an alternative approach.
- This aims to mitigate negative effects of ovarian stimulation on the endometrium and reduce OHSS risk.
Purpose of the Study:
- To evaluate and compare live birth rates between freeze-all and fresh embryo transfer strategies.
- To assess the safety and efficacy of freeze-all approach versus fresh embryo transfer.
Main Methods:
- Review of existing studies comparing freeze-all and fresh embryo transfer strategies.
- Analysis of live birth rates, safety endpoints, and other factors like time to pregnancy and cost-effectiveness.
Main Results:
- Inconsistent live birth rate data between freeze-all and fresh embryo transfer.
- Freeze-all strategy may lower OHSS risk, but benefits vary based on patient characteristics and embryo stage.
- Mixed safety outcomes observed, with some complications reduced and others increased with freeze-all.
Conclusions:
- The freeze-all strategy is not universally beneficial and its effectiveness varies among patients.
- A personalized approach, considering individual patient factors and preferences, is recommended.
- Further research is needed to clarify optimal patient selection for freeze-all strategies.
Keywords:
ICSIIVFcost-effectivenessfreeze-allfresh embryo transferfrozen embryo transferlive birth rateovarian hyperstimulation syndromeMore Related Videos
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