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The use of N-acetylcysteine long after an acetaminophen overdose in mice
Toxicology Letters
|March 1, 1987
Abstract:
N-Acetylcysteine (NAC), given to mice 5 h after an LD50 dose of acetaminophen, decreased 24-h survival to 33%. The reduction in survival observed for late NAC is significantly lower than the survival observed for the LD50 dose alone (53%), and is in sharp contrast to the 100% survival reported for the early use of NAC.
