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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Related Experiment Video

Updated: Sep 21, 2025

Human Blastocyst Biopsy and Vitrification
10:59

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

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What is the best strategy for slowly developing blastocysts?

Sophie Loubersac1, Anaïs Inquel2, Tiphaine Lefebvre3

  • 1CHU Nantes, Nantes Université, Service de Medecine et Biologie de la Reproduction et Gynecologie Medicale, Nantes, France; Nantes Université, CHU Nantes, INSERM, Center for Research in Transplantation ans Translational Immunology, UMR 1064, F-44000 Nantes, France; Université de Nantes, Nantes, France.

Journal of Gynecology Obstetrics and Human Reproduction
|May 31, 2022
PubMed
Summary

Fresh day 5 blastocyst transfers yield higher pregnancy rates than day 6 transfers. Slowly developing day 5 blastocysts can be transferred fresh on day 5, showing similar outcomes to day 6 transfers.

Keywords:
BlastocystDay 6IVFSingle embryo transfer

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • In Vitro Fertilization

Background:

  • Blastocyst transfer timing impacts IVF success.
  • Optimal strategy for slowly developing blastocysts remains debated.

Purpose of the Study:

  • To compare clinical outcomes of fresh day 5 vs. day 6 blastocyst transfers.
  • To evaluate strategies for managing slowly developing blastocysts on day 5.

Main Methods:

  • Retrospective analysis of 1093 single blastocyst transfer cycles (Jan 2016 - Dec 2018).
  • Four groups: Day 5 fresh (fully expanded/slowly developing), Day 6 fresh, Day 6 frozen-thawed.
  • Outcomes assessed: clinical pregnancy and live birth rates.

Main Results:

  • Fresh day 5 expanded blastocyst transfer showed significantly higher rates than all other groups.
  • No significant difference in outcomes between day 5 fresh slowly developing, day 6 fresh, and day 6 frozen-thawed transfers.
  • Slowly developing day 5 blastocysts have lower implantation potential than expanded ones.

Conclusions:

  • Fresh day 5 expanded blastocyst transfer is superior for maximizing pregnancy and live birth rates.
  • Slowly developing day 5 blastocysts can be transferred fresh on day 5 with acceptable outcomes.
  • Avoids prolonged culture or freezing when expanded blastocysts are unavailable on day 5.