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Published on: April 26, 2024
Antiresorptive treatments for corticosteroid-induced osteoporosis: a Bayesian network meta-analysis
Filippo Migliorini1, Giorgia Colarossi1, Jörg Eschweiler1
1Department of Orthopaedic and Trauma Surgery, University Clinic Aachen, RWTH Aachen University Clinic, Aachen 52074, Germany.
Introduction:
Corticosteroid-induced osteoporosis (CIO) is the most common type of secondary osteoporosis, leading to fractures, and increased morbidity and mortality.
Source Of Data:
Pubmed, EMBASE, Scopus and Google Scholar databases.
Areas Of Agreement:
Prolonged glucocorticoids administration leads to secondary osteoporosis.
Areas Of Controversy:
The optimal management for CIO is controversial.
Growing Points:
The present study compared bone mineral density, fractures and adverse events in patients undergoing treatment with risedronate, alendronate, zoledronate, denosumab or etidronate for CIO.
Areas Timely For Developing Research:
For selected patients with CIO, alendronate performed better overall. These results must be interpreted within the limitations of the present study.
Level Of Evidence:
I, Bayesian network meta-analysis of randomized clinical trials.
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