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Mangosteen Inhibits Growth and Survival of Cervical Cancer Cells

Nathan T Givens1, Lei Zhao2, Ziwen Zhu3

  • 1Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA, U.S.A.

Anticancer Research
|May 31, 2022
PubMed
Abstract

Insights

Mangosteen extract (ME) inhibits cervical cancer cell growth and survival by down-regulating key cell cycle and apoptosis-related molecules. This suggests ME as a potential candidate for novel cancer immunotherapy development.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Research

Background:

  • Cervical cancer remains a significant health concern, particularly in late stages where treatment efficacy is limited.
  • There is an urgent need for novel anti-cancer therapies.
  • Mangosteen, a tropical fruit, contains xanthones with known anti-cancer properties.

Purpose of the Study:

  • To investigate the anti-cancer effects of mangosteen extract (ME) on SiHa cervical cancer cells.
  • To explore the molecular mechanisms underlying ME's action.

Main Methods:

  • In vitro assays including clonogenic survival, cell proliferation, TUNEL staining, and caspase-3 activity were employed.
  • Gene expression analysis using RT-PCR investigated molecular targets.
  • Statistical significance was determined using Student's t-test (p<0.05).

Main Results:

  • Mangosteen extract (ME) significantly inhibited the growth and proliferation of SiHa cervical cancer cells.
  • ME treatment induced apoptosis in these cancer cells.
  • Down-regulation of pro-proliferative cyclins (B, D, E) and anti-apoptotic proteins (FLIP, survivin) was observed.

Conclusions:

  • Mangosteen extract (ME) effectively impedes cervical cancer cell growth and survival.
  • The mechanism involves the down-regulation of cyclins B, D, E, FLIP, and survivin.
  • ME shows promise as a potential therapeutic strategy for developing targeted cancer immunotherapies.
Keywords:
Mangosteenapoptosiscervical cancerproliferation

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