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Related Experiment Video

Updated: Sep 21, 2025

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Extracellular vesicles in kidney disease.

Cristina Grange¹, Benedetta Bussolati²

¹Department of Medical Sciences, University of Turin, Turin, Italy.

Nature Reviews. Nephrology

|May 31, 2022

Summary

Extracellular vesicles (EVs) are key in cell communication and kidney health. EVs show potential for diagnosing kidney disease and may be used therapeutically for regeneration and drug delivery.

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Last Updated: Sep 21, 2025

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Setting a Successful Sorting for Extracellular Vesicle Isolation

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Published on: October 11, 2024

Area of Science:

Cell Biology
Nephrology
Biotechnology

Background:

Extracellular vesicles (EVs) are released by most cells and mediate intercellular communication.
EVs play critical roles in kidney physiology and pathology, influencing cell crosstalk and organ interactions.
Their molecular cargo reflects the originating cell's status, suggesting diagnostic potential.

Purpose of the Study:

To review the role of EVs in kidney function and disease.
To explore the diagnostic and prognostic potential of EVs in nephrology.
To discuss the therapeutic applications of EVs, including kidney regeneration and drug delivery.

Main Methods:

Literature review of studies on extracellular vesicles in kidney research.
Analysis of the molecular mechanisms of EV-mediated cell communication in the kidney.
Evaluation of preclinical data on EV-based therapeutic strategies for kidney diseases.

Main Results:

Urinary and circulating EVs mediate critical crosstalk in kidney health and disease.
EVs' molecular profiles offer potential biomarkers for kidney conditions.
Preclinical studies demonstrate EV capacity to promote kidney regeneration and reduce fibrosis.

Conclusions:

Extracellular vesicles are pivotal in kidney pathophysiology and hold significant promise for diagnostics.
EVs derived from stem cells are particularly promising for regenerative therapies in kidney disease.
Standardization and scalable production are crucial for the clinical translation of EV-based therapeutics.