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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

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Prognostic value of triglyceride glucose (TyG) index in patients with acute decompensated heart failure

Rong Huang1, Ziyan Wang2, Jianzhou Chen1

  • 1Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.

Cardiovascular Diabetology
|June 1, 2022
PubMed

Insights

The triglyceride glucose (TyG) index, a marker of insulin resistance, independently predicts poor prognosis in acute decompensated heart failure (ADHF) patients. Elevated TyG index is associated with increased risks of all-cause death, cardiovascular death, and major adverse cardiac and cerebral events.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • The triglyceride glucose (TyG) index is a recognized indicator of insulin resistance and a predictor of cardiovascular disease.
  • Its prognostic significance in patients with acute decompensated heart failure (ADHF) is not well-established.

Purpose of the Study:

  • To investigate the association between the TyG index and clinical outcomes in patients hospitalized with ADHF.
  • To determine if the TyG index can serve as a prognostic marker for risk stratification in ADHF.

Main Methods:

  • A retrospective study of 932 ADHF patients, with TyG index calculated using fasting triglyceride and glucose levels.
  • Patients categorized into tertiles based on TyG index. Primary endpoints included all-cause death, cardiovascular death, and major adverse cardiac and cerebral events (MACCEs).
  • Multivariate Cox proportional hazard models and restricted cubic spline analysis were employed to assess associations.

Main Results:

  • During a median follow-up of 478 days, 15.0% experienced all-cause death, 11.1% CV death, and 47.9% MACCEs.
  • The highest TyG index tertile was significantly associated with increased risks of all-cause death (HR 2.09), CV death (HR 2.31), and MACCEs (HR 1.83) after multivariate adjustment.
  • Restricted cubic spline analysis revealed a continuous increase in risk with rising TyG index values.

Conclusions:

  • An elevated TyG index is an independent predictor of adverse outcomes in patients with ADHF.
  • The TyG index demonstrates utility in the risk stratification of ADHF patients, aiding in prognosis assessment.
Abstract

Keywords:
Acute decompensated heart failureAll-cause deathCardiovascular deathMajor adverse cardiac and cerebral eventsTriglyceride glucose index

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