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Updated: Sep 21, 2025

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices
Published on: June 13, 2025
[Current Interventional Management of Acute Upper Gastrointestinal Bleeding].
1Department of Gastroenterology and Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, Sichuan University, Chengdu 610041, China.
Severe upper gastrointestinal bleeding (UGIB) may require interventional treatment. Endovascular embolization and transjugular intrahepatic portosystemic shunts offer effective options for high-risk patients, reducing rebleeding and mortality.
Area of Science:
- Gastroenterology
- Interventional Radiology
Background:
- Upper gastrointestinal bleeding (UGIB) is a critical condition with significant mortality.
- Endoscopic therapy is standard for stable patients, but 5-10% require advanced interventions.
Purpose of the Study:
- To review the role of interventional treatments in massive UGIB.
- To highlight endovascular embolization and TIPS for refractory cases.
Main Methods:
- Review of clinical experience in managing massive UGIB.
- Focus on interventional strategies for non-variceal and cirrhotic patients.
Main Results:
- Endovascular embolization is a primary therapy for refractory non-variceal UGIB post-endoscopy.
- Preemptive transjugular intrahepatic portosystemic shunt (TIPS) significantly lowers failure and mortality in cirrhotic patients with varices.
Conclusions:
- Interventional treatments are crucial for managing massive UGIB.
- Embolization and TIPS are vital for high-risk patient groups, improving outcomes.
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