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Updated: Sep 21, 2025
Cryosectioning Method for Microdissection of Murine Colonic Mucosa
Published on: July 12, 2015
Analysis of Clinical and Histopathological Findings in Microscopic Colitis
Gozde Topel1, Ebru Cakir, Ilgin Aydin
1Department of Pathology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, IZMIR, TURKEY.
This study analyzed microscopic colitis cases in Turkey, finding distinct demographic and histopathological features compared to global data. Awareness of these features is crucial for accurate diagnosis of this common cause of chronic diarrhea.
Area of Science:
- Gastroenterology
- Pathology
- Internal Medicine
Background:
- Microscopic colitis presents with chronic diarrhea, normal endoscopy, and specific histopathology.
- Subtypes include collagenous colitis, lymphocytic colitis, and incomplete microscopic colitis.
Purpose of the Study:
- To analyze detailed clinicopathological parameters of microscopic colitis in the Turkish population.
- To compare findings with existing international literature.
Main Methods:
- Retrospective analysis of 53 microscopic colitis cases diagnosed between 2010 and 2019.
- Evaluation included collagenous colitis (37), lymphocytic colitis (7), and incomplete microscopic colitis (9).
Main Results:
- Lymphoplasmacytosis was present in all cases.
- Eosinophilic infiltration was notable in collagenous (75.7%) and lymphocytic (57.1%) colitis.
- Concomitant Celiac disease was found in 29% of lymphocytic colitis cases; PPIs and NSAIDs were common drug uses.
Conclusions:
- The Turkish cohort showed a lower mean age and male predominance in lymphocytic and incomplete microscopic colitis, differing from literature.
- Findings suggest ethnic variations in microscopic colitis susceptibility.
- Key diagnostic features include lymphoplasmacytosis, eosinophilic infiltration, and epithelial damage, essential for identifying incomplete cases.
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