Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Konjac oligosaccharides promote calcium absorption and bone health in growing mice.

Food & function·2026

Same author

Oral Administration of Metal-Phenolic-Inspired Curcumin Self-Assemblies for Colitis Alleviation.

Journal of agricultural and food chemistry·2026

Same author

Mechanistic Insights into Tannic Acid-Polyethylene Glycol-Induced Self-Assembly of Nobiletin: From Molecular Binding to Enhanced Bioavailability.

ACS biomaterials science & engineering·2025

Same author

Prospects and Challenges of Umami in Edible Fungi: Biological Sources, Structure-Function Relationship, Production, Mechanism, and Evaluation.

Comprehensive reviews in food science and food safety·2025

Same author

Effects of oligosaccharides, sodium carboxymethyl cellulose and d-allulose as a compound improver on the quality of sugar-reduced bread.

Journal of the science of food and agriculture·2024

Same author

Citrus Polymethoxyflavones Regulate against Aging-Associated Diseases: Advances in Biological Mechanisms Responsible for Their Regulation.

Journal of agricultural and food chemistry·2024

Search research articles

Related Experiment Video

Updated: Sep 21, 2025

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Coordination-Driven Metal-Polyphenolic Nanoparticles toward Effective Anticancer Therapy.

Di Wu¹, Bin Zhou², Jing Li¹

¹College of Food Science and Technology, Huazhong Agricultural University, Key Laboratory of Environment Correlative Dietology, Ministry of Education, Wuhan, 430070, China.

Advanced Healthcare Materials

|June 1, 2022

Summary

Researchers developed a novel metal-phenolic coating using tannic acid and metal ions to stabilize hydrophobic drugs. This biocompatible nanoparticle system enhances drug delivery and exhibits superior anti-cancer activity by promoting apoptosis and inhibiting metastasis.

Keywords:

anti-tumors drug delivery metal-phenolic networks nanoparticles

More Related Videos

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Related Experiment Videos

Last Updated: Sep 21, 2025

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Area of Science:

Materials Science
Biomedical Engineering
Nanotechnology

Background:

Stabilizing bioactive components, particularly hydrophobic factors, is crucial for enhancing their biological activity.
Metal-phenolic coordination chemistry offers a versatile platform for creating functional nanomaterials.

Purpose of the Study:

To synthesize biocompatible and biodegradable thin films using tannic acid and trivalent metal ions (Fe3+ or Al3+).
To utilize these films for encapsulating hydrophobic drugs (nobiletin) for controlled release in cancer therapy.
To evaluate the efficacy of the drug-loaded nanoparticles in vitro and in vivo.

Main Methods:

Fabrication of metal-phenolic coordination films using tannic acid and Fe3+ or Al3+ ions.
Encapsulation of nobiletin within the metal-phenolic matrix to form drug-loaded nanoparticles (NPs) of approximately 200 nm.
In vitro and in vivo evaluation of NP colloidal stability, drug release kinetics, biocompatibility, and anti-tumor activity.

Main Results:

The assembled system formed uniform drug-loaded nanoparticles (NPs) with enhanced colloidal stability and reduced premature drug leakage.
The metal-phenolic coating demonstrated high cell biocompatibility, serving as an effective drug delivery vector.
The fabricated drug NPs exhibited significant anti-tumor activity, superior to naked drug formulations, by inducing apoptosis and inhibiting metastasis.

Conclusions:

Metal-phenolic coordination provides an effective and straightforward method for coating hydrophobic drugs.
This approach yields a promising nanocarrier for controlled drug delivery in cancer therapy.
The developed system shows potential for enhanced biomedical applications in cancer treatment.