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Updated: Sep 21, 2025
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Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
Published on: March 13, 2018
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Video-oculographic biomarkers for evaluating vertical ocular dysfunction in progressive supranuclear palsy
Andrea Quattrone1, Marianna Crasà2, Maurizio Morelli1
1Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Parkinsonism & Related Disorders
|June 1, 2022
Summary
Video-oculography (VOG) reveals that combining saccade amplitude and peak velocity in vertical gaze is the best method for diagnosing progressive supranuclear palsy (PSP) and distinguishing it from Parkinson's disease (PD). Peak velocity alone is not sensitive enough for PSP diagnosis.
Area of Science:
- Neuroscience
- Ophthalmology
- Neurology
Background:
- Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) are neurodegenerative disorders with overlapping symptoms.
- Saccadic eye movement abnormalities, particularly in vertical saccades, are characteristic of PSP.
- Differentiating PSP from PD using clinical and oculographic measures is crucial for accurate diagnosis and management.
Purpose of the Study:
- To investigate the diagnostic performance of video-oculography (VOG) parameters for differentiating PSP from PD.
- To identify the most effective VOG biomarkers for PSP diagnosis.
Main Methods:
- Fifty-one PSP patients, 113 PD patients, and 40 controls were enrolled.
- Video-oculography (VOG) was used to assess saccadic amplitude, peak velocity, and their product (AxV) in vertical gaze.
- Diagnostic performance was evaluated using specificity, sensitivity, and accuracy.
Main Results:
- PSP patients exhibited significantly reduced vertical saccadic amplitude and peak velocity compared to PD patients and controls.
- The AxV product demonstrated high specificity (94.7%) and sensitivity (84.3%) in distinguishing PSP from PD, with an overall accuracy of 91.5%.
- Peak velocity alone showed low sensitivity (54.7%) for PSP classification.
Conclusions:
- Peak velocity of vertical saccades is not a sufficiently sensitive parameter for diagnosing PSP when used alone.
- A novel index combining saccadic amplitude and peak velocity in vertical gaze represents the most suitable VOG biomarker for differentiating PSP from PD.
