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Insight into the role of DPP-4 in fibrotic wound healing
Kai-Wen Zhang1, Si-Yu Liu1, Yuan Jia1
1Department of Medicine, Institute of Integrated Traditional Chinese and Western Medicine, Wuxi Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Wuxi, China.
Abstract:
Wound healing is a complex and long-term process consisting of hemostasis, inflammation, proliferation, and maturation/remodeling. These four stages overlap and influence each other; they affect wound healing in different ways, and if they do not function perfectly, they may cause scarring, proliferative scarring and keloid formation. A therapeutic target affecting wound healing in multiple ways will help the healing process proceed more effectively. DPP-4/CD26 is a multifunctional dimorphic glycoprotein widely distributed on the surface of a variety of cells, including fibroblasts and keratin-forming cells. It has been found to affect periwound inflammation, re-epithelialization, extracellular matrix secretion and skin fibrosis and is a potential target for promoting wound healing and inhibiting scar formation. After presenting a brief introduction of the wound healing process and DPP-4/CD26, this paper summarizes the effects of DPP-4/CD26 on cells involved in different stages of wound healing and discusses the feasibility of DPP-4/CD26 as a multifunctional target for the treatment of wound healing and inhibition of scar formation.
Insights
Dipeptidyl peptidase-4 (DPP-4/CD26) influences wound healing stages and scar formation. Targeting DPP-4/CD26 offers a promising strategy for effective wound repair and scar reduction.
Area of Science:
- Biochemistry
- Dermatology
- Regenerative Medicine
Background:
- Wound healing involves complex, overlapping stages: hemostasis, inflammation, proliferation, and remodeling.
- Imperfect wound healing can lead to scarring, including hypertrophic scars and keloids.
- A therapeutic target influencing multiple healing aspects is needed for improved outcomes.
Purpose of the Study:
- To explore the role of dipeptidyl peptidase-4 (DPP-4/CD26) in wound healing.
- To evaluate DPP-4/CD26 as a potential target for promoting wound healing and inhibiting scar formation.
Main Methods:
- Review of the wound healing process and the characteristics of DPP-4/CD26.
- Summary of DPP-4/CD26's effects on cells crucial to wound healing stages.
- Discussion of DPP-4/CD26's therapeutic potential.
Main Results:
- DPP-4/CD26 is a glycoprotein found on fibroblasts and keratinocytes.
- DPP-4/CD26 impacts periwound inflammation, re-epithelialization, extracellular matrix secretion, and fibrosis.
- These effects suggest DPP-4/CD26 influences multiple facets of wound repair.
Conclusions:
- DPP-4/CD26 plays a significant role in modulating cellular activities during wound healing.
- Targeting DPP-4/CD26 presents a viable strategy for enhancing wound healing and mitigating scar development.
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