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Carcinogenic components of tobacco and tobacco smoke: A 2022 update

Yupeng Li1, Stephen S Hecht2

  • 1Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|June 1, 2022
PubMed

Insights

This study identifies 83 carcinogens in tobacco products and smoke, with levels remaining unchanged. Continued surveillance and regulatory action are crucial for reducing cancer risks associated with tobacco use.

Area of Science:

  • Environmental Health
  • Toxicology
  • Public Health

Background:

  • Tobacco and its smoke contain over 9500 chemicals, many hazardous.
  • Regulatory agencies recognize numerous tobacco constituents as harmful.
  • The U.S. Food and Drug Administration (FDA) listed 79 carcinogens in 2012.

Purpose of the Study:

  • To provide an updated list of International Agency for Research on Cancer (IARC)-classified carcinogens in unburned tobacco and mainstream smoke.
  • To report occurrence levels of these carcinogens since 2012.
  • To assess trends in carcinogen levels over the past decade.

Main Methods:

  • Literature review of published data on carcinogen levels in tobacco products and smoke.
  • Compilation of IARC-classified carcinogens identified since 2012.
  • Analysis of occurrence levels and trends for identified carcinogens.

Main Results:

  • A total of 83 carcinogens identified: 37 in unburned tobacco and 80 in tobacco smoke.
  • Occurrence levels reported for these carcinogens since 2012.
  • No clear decreasing trends observed for any of the identified tobacco carcinogens.

Conclusions:

  • Continued surveillance of tobacco carcinogen levels is necessary.
  • Regulatory actions are essential to control carcinogen levels in tobacco products.
  • Effective control may lead to reduced risks of cancer and other tobacco-related diseases.

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