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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

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Spray dried inhalable ivacaftor co-amorphous microparticle formulations with leucine achieved enhanced in vitro

Jian Guan1, Huiya Yuan2, Shihui Yu3

  • 1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, United States.

International Journal of Pharmaceutics
|June 1, 2022
PubMed

Keywords:
Co-amorphousDissolutionDry powder inhalationIvacaftorLeucine

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