Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenergic Agonists: Mixed-Action Agents01:28

Adrenergic Agonists: Mixed-Action Agents

935
Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
935
Adrenergic Agonists: Indirect-Acting Agents01:25

Adrenergic Agonists: Indirect-Acting Agents

1.9K
Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
1.9K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

6.7K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.7K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

346
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
346
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

14.0K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
14.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On-Demand Control of Lanthanide Optical Dynamics via Pumping-Flux Modulation.

Nano letters·2025
Same author

Picropodophyllin induces ferroptosis via blockage of AKT/NRF2/SLC7A11 and AKT/NRF2/SLC40A1 axes in hepatocellular carcinoma as a natural IGF1R inhibitor.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025
Same author

Cerium-Organic Framework and Resveratrol Composite Hydrogel Scaffold with Dual Antioxidant Activity for Enhanced Bone Regeneration.

ACS applied materials & interfaces·2025
Same author

Can levels of HPV vaccine knowledge mitigate HPV vaccine hesitation among guardians of children aged 9-14 years? A moderated mediation model.

Vaccine·2025
Same author

Split-belt treadmill training improves gait symmetry and lower limb function in patients with stroke.

Scientific reports·2025
Same author

[Effect of <i>TBL1XR1</i> Mutation on Cell Biological Characteristics of Diffuse Large B-Cell Lymphoma].

Zhongguo shi yan xue ye xue za zhi·2025
Same journal

An AAV-based bioluminescent reporter reveals dynamic YAP/TAZ-TEAD transcriptional activity during liver injury.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same journal

Small-molecule LIFR inhibitors attenuate renal tubulointerstitial fibrosis.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same journal

Early melatonin supplementation partially delays gastrointestinal aging.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same journal

DNA methylation-mediated downregulation of MEIS2 correlates with tumor development and progression in gastric cancer.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same journal

A proliferation-inducing ligand enhances the anti-tumor effect of BCMA CAR T-cell through inhibition of soluble BCMA.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same journal

Emerging roles of SIRT7 in metabolic homeostasis and related disorders.

Biochimica et biophysica acta. Molecular basis of disease·2026
See all related articles

Related Experiment Video

Updated: Sep 21, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral &#946;-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

322

Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ.

Bao-Ying Luo1, Jie Zhou2, Dan Guo3

  • 1Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, PR China; Zhangzhou Health Vocational College, Zhangzhou 363000, PR China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|June 1, 2022
PubMed
Summary
This summary is machine-generated.

Methamphetamine (METH) abuse causes thoracic aortic aneurysm/dissection (TAAD) by increasing matrix metalloproteinases and smooth muscle cell apoptosis. CCAAT-enhancer binding protein β (C/EBPβ) is a key mediator in METH-induced TAAD, offering potential diagnostic and therapeutic targets.

Keywords:
ApoptosisC/EBPβMMP2/9MethamphetamineThoracic aortic aneurysm/dissection

More Related Videos

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of &#946;-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

9.7K
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

38.1K

Related Experiment Videos

Last Updated: Sep 21, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral &#946;-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

322
Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of &#946;-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

9.7K
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

38.1K

Area of Science:

  • Cardiovascular Research
  • Toxicology
  • Molecular Biology

Background:

  • Thoracic aortic aneurysm/dissection (TAAD) is a dangerous condition.
  • Methamphetamine (METH) use is linked to TAAD, but a causal link is unproven.

Purpose of the Study:

  • To establish if METH causes TAAD.
  • To identify the molecular mechanisms underlying METH-induced TAAD.

Main Methods:

  • A rat model of TAAD was created using METH and a lysyl oxidase inhibitor (BAPN).
  • Gene and protein expression, enzyme activity, and cell apoptosis were analyzed.
  • Signaling pathways involving C/EBPβ, MMP2/9, and apoptosis regulators were investigated.

Main Results:

  • METH and BAPN induced TAAD in 60% of rats, increasing MMP2/MMP9 activity and elastin damage.
  • METH elevated C/EBPβ expression via Smad3/ERK signaling, promoting MMP2/9.
  • C/EBPβ inhibition reduced TAAD and MMP expression; METH increased SMC apoptosis through C/EBPβ-mediated pathways.
  • Elevated C/EBPβ, MMPs, and apoptosis markers were found in human TAAD aortas.

Conclusions:

  • METH exposure causally induces TAAD.
  • C/EBPβ is a critical mediator of METH-induced TAAD, driving elastin damage and cell loss.
  • C/EBPβ presents a potential target for TAAD diagnosis or treatment.