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Updated: Sep 21, 2025

Measurement of the Pressure-volume Curve in Mouse Lungs
Published on: January 27, 2015
Relationship between concavity of the flow-volume loop and small airway measures in smokers with normal spirometry
Hooria Alowiwi1,2, Stella Watson3, Kanika Jetmalani4
1Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, 431 Glebe Point Rd, Sydney, NSW, 2037, Australia. hooria.alowiwi@sydney.edu.au.
Background:
There is increasing evidence of small airway abnormalities in smokers despite normal spirometry. The concavity in the descending limb of the maximum expiratory flow curve (MEFV) is a recognised feature of obstruction and can provide information beyond FEV1, and potentially early smoking-related damage. We aimed to evaluate concavity measures compared to known small airway measurements.
Methods:
Eighty smokers with normal spirometry had small airway function assessed: multiple breath nitrogen washout (MBNW) from which ventilation heterogeneity in the diffusion-dependent acinar (Sacin) and convection-dependent conductive (Scond) airways were assessed, and impulse oscillometry system (IOS) from which respiratory resistance and reactance at 5 Hz (R5 and X5) were measured. Concavity measures were calculated from the MEFV, partitioned into global and peripheral concavity.
Results:
We found abnormal peripheral and global concavity as well as acinar ventilation heterogeneity are common in "normal" smokers. Concavity measures were not related to either MBNW or IOS measurements.
Conclusion:
Abnormalities in concavity indices and MBNW or oscillometry parameters are common in smokers despite normal spirometry. However, these measures likely reflect different mechanisms of peripheral airway dysfunction.
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