Elaborate design of shell component for manipulating the sustained release behavior from core-shell nanofibres
Yubo Liu1, Xiaohong Chen1,2, Yuhang Gao1
1School of Materials and Chemistry, University of Shanghai for Science & Technology, 516 Jungong Road, Yangpu District, Shanghai, 200093, China.
Journal of Nanobiotechnology
|June 1, 2022
Summary
Researchers developed novel core-shell fibers using modified triaxial electrospinning to enhance drug delivery. These functional fibers successfully combined high hydrophilicity with controlled, sustained drug release, overcoming previous limitations in material design for drug carriers.
Area of Science:
- Biomaterials Engineering
- Nanotechnology
- Drug Delivery Systems
Background:
- Developing advanced functional materials requires combining nanostructures and materials.
- Achieving both hydrophilicity and sustained drug release in drug delivery systems presents a significant challenge.
- Existing materials struggle to simultaneously improve sustained-release properties and increase hydrophilicity.
Purpose of the Study:
- To fabricate functional core-shell fibers with tunable hydrophilicity and drug release profiles.
- To overcome the limitations of current drug delivery systems regarding hydrophilicity and sustained release.
- To explore a modified triaxial electrospinning strategy for advanced material design.
Main Methods:
- Utilized a modified triaxial electrospinning technique to create core-shell fibers.
- Designed the inner layer with Cur (model drug), the middle layer with polyethylene glycol (PEG) for hydrophilicity, and cellulose acetate (CA) as the polymeric matrix.
- Varied PEG concentration to manipulate fiber properties and drug release.
Main Results:
- Confirmed clear core-shell structures in F2-F4 fibers via SEM and TEM.
- Verified amorphous form of Cur and good CA matrix compatibility using XRD and FTIR.
- Demonstrated significantly enhanced hydrophilicity (120s vs 0.5h) and swelling (4600%) in functional fibers.
- Achieved 96h sustained release with 1% PEG (F2) and 12h release with >3% PEG (F3, F4).
Conclusions:
- Successfully produced functional core-shell fibers (F2-F4) using modified triaxial electrospinning.
- The strategy effectively manipulates hydrophilicity and sustained drug release in drug carriers.
- This approach offers a promising method for preparing functional nanomaterials and advancing drug delivery systems.
