Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

62
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
62
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

49
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
49
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

36
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
36
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

34
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
34
The Aorta01:14

The Aorta

1.4K
The aorta is the largest artery in the human body. It originates from the left ventricle of the heart and extends down to the abdomen, where it splits into two smaller arteries. Structurally, it can be divided into four main parts: the ascending aorta, the aortic arch, the thoracic aorta, and the abdominal aorta.
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
1.4K
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

56
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
56

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural History of Tricuspid Regurgitation After Transcatheter Aortic Valve Implantation.

Journal of the American Heart Association·2025
Same author

Sex differences in pre- and post-surgical left ventricular remodelling and outcomes in primary mitral regurgitation.

European heart journal. Cardiovascular Imaging·2025
Same author

Cerebral Embolic Protection Devices in Transcatheter Aortic Valve Implantation: Meta-Analysis With Trial Sequential Analysis.

Journal of the American Heart Association·2025
Same author

Predicting Late Adverse Events in Uncomplicated Stanford Type B Aortic Dissection: Results From the ROADMAP Validation Study.

Circulation. Cardiovascular imaging·2025
Same author

Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease.

Circulation research·2025
Same author

Moderate Aortic Valve Stenosis Is Associated With Increased Mortality Rate and Lifetime Loss: Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data of 409 680 Patients.

Journal of the American Heart Association·2024
Same journal

Erratum.

Journal of cardiac surgery·2023
Same journal

Validity of direct bilateral axillary arterial cannulation in emergency surgery for acute type A aortic dissection.

Journal of cardiac surgery·2023
Same journal

Evaluation of midterm outcomes after Shone's complex surgery: Analysis of reoperation and mortality risk factors.

Journal of cardiac surgery·2023
Same journal

Subannular procedures on papillary muscles for secondary mitral valve regurgitation repair.

Journal of cardiac surgery·2022
Same journal

Safety of apixaban and rivaroxaban compared to warfarin after cardiac surgery.

Journal of cardiac surgery·2022
Same journal

Impact of rapid rehabilitation surgery on perioperative nursing in patients undergoing cardiac surgery: A meta-analysis.

Journal of cardiac surgery·2022
See all related articles

Related Experiment Video

Updated: Sep 21, 2025

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.5K

Aortic root enlargement: Just do it.

Sarah Yousef1, Ibrahim Sultan1,2

  • 1Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Journal of Cardiac Surgery
|June 1, 2022
PubMed
Summary
This summary is machine-generated.

Aortic root enlargement (ARE) may aid aortic valve replacement (AVR) in patients with small aortic annuli. However, the additional risks and complications associated with ARE require further investigation.

Keywords:
AVRManougianSAVRaortic root enlargementaortic valve

More Related Videos

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.2K
Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
04:56

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm

Published on: August 1, 2025

137

Related Experiment Videos

Last Updated: Sep 21, 2025

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.5K
Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.2K
Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
04:56

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm

Published on: August 1, 2025

137

Area of Science:

  • Cardiac Surgery
  • Aortic Valve Disease
  • Surgical Innovation

Background:

  • Aortic valve replacement (AVR) is a common procedure for aortic valve disease.
  • Small aortic annuli can pose challenges during AVR, potentially requiring aortic root enlargement (ARE).
  • The added morbidity of ARE in conjunction with AVR is not fully elucidated.

Purpose of the Study:

  • To evaluate the incremental morbidity associated with aortic root enlargement (ARE) when performed as an adjunct to aortic valve replacement (AVR).
  • To understand the risks and complications specific to the ARE procedure in the context of AVR.

Main Methods:

  • Retrospective analysis of patient data undergoing AVR with and without ARE.
  • Comparison of perioperative and postoperative outcomes, including mortality, morbidity, and resource utilization.
  • Statistical analysis to identify significant differences in outcomes between the two groups.

Main Results:

  • Preliminary data suggests a potential increase in certain complications with ARE.
  • Specific complications such as bleeding and prolonged ventilation may be more frequent.
  • Further analysis is needed to confirm statistical significance and clinical impact.

Conclusions:

  • Aortic root enlargement (ARE) may be necessary for select patients undergoing aortic valve replacement (AVR) with small aortic annuli.
  • The incremental morbidity of ARE requires careful consideration and further robust investigation.
  • Understanding these risks is crucial for patient selection and surgical planning.