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Compensatory elevated serum intermedin levels are associated with increased vascular calcification in hemodialysis

Wenhan Bao1, Lian He2, Aihua Zhang3

  • 1Department of Nephrology, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China.

International Urology and Nephrology
|June 1, 2022
PubMed

Insights

Serum intermedin (IMD) levels are lower in hemodialysis patients and linked to vascular calcification (VC). Lower IMD, higher PTH, and older age independently predict VC in these patients.

Area of Science:

  • Nephrology
  • Cardiovascular Biology
  • Biochemistry

Background:

  • Vascular calcification (VC) is common and fatal in dialysis patients, with unclear mechanisms.
  • Intermedin (IMD), a bioactive peptide, is investigated for its potential role in VC.
  • This study examines serum IMD levels in hemodialysis (HD) patients and their association with VC.

Purpose of the Study:

  • To evaluate serum intermedin (IMD) levels in patients undergoing maintenance hemodialysis (HD).
  • To determine the relationship between serum IMD levels and vascular calcification (VC) in HD patients.
  • To identify other factors associated with VC in this population.

Main Methods:

  • Radioimmunoassay (RIA) was used to measure serum IMD levels.
  • Abdominal aortic calcification (AAC) scores were used to assess VC.
  • 116 HD patients and 52 healthy controls were included.

Main Results:

  • HD patients exhibited significantly lower serum IMD levels compared to controls.
  • Lower IMD levels correlated negatively with serum phosphate.
  • Reduced IMD levels (< median) were associated with a lower incidence of VC.
  • Independent predictors for VC included low serum IMD (<24.89 pg/ml), high serum iPTH, and older age.

Conclusions:

  • Serum IMD levels are significantly reduced in HD patients.
  • Lower IMD levels, alongside higher PTH and older age, are independent determinants of VC in HD patients.
  • This study is the first to investigate the link between IMD and VC in dialysis patients.
Abstract

Keywords:
Chronic kidney diseaseHemodialysisIntermedinVascular calcification

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