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The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions

Mohammad Rafi Khezri1, Reza Jafari2, Keyvan Yousefi3

  • 1Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.

Experimental and Molecular Pathology
|June 1, 2022
PubMed

Insights

The Phosphatidylinositol 3 kinase (PI3K)/Protein kinase B (AKT) pathway is crucial for cell functions and its dysregulation drives cancer. This review summarizes the PI3K/AKT pathway

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Cellular processes like survival and proliferation are tightly regulated.
  • Aberrant signaling pathways, including PI3K/AKT, are implicated in cancer development.
  • The PI3K/AKT pathway controls critical cellular functions.

Purpose of the Study:

  • To review the role of the PI3K/AKT signaling pathway in various cancers.
  • To explore the relationship between PI3K/AKT pathway dysregulation and cancer initiation/progression.
  • To summarize therapeutic strategies targeting the PI3K/AKT pathway.

Main Methods:

  • Literature review of scientific studies.
  • Analysis of research on PI3K/AKT pathway in cancer.
  • Synthesis of information on therapeutic interventions.

Main Results:

  • The PI3K/AKT pathway is frequently dysregulated in cancer.
  • This pathway influences cell survival, proliferation, and metabolism, contributing to tumorigenesis.
  • Targeting the PI3K/AKT pathway shows therapeutic potential.

Conclusions:

  • The PI3K/AKT pathway is a significant contributor to cancer.
  • Understanding this pathway is vital for developing targeted cancer therapies.
  • Further research into PI3K/AKT inhibitors is warranted.
Keywords:
AngiogenesisApoptosisCancerPI3K/AKT

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