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Ischemic Stroke and SARS-CoV-2 Infection: The Bidirectional Pathology and Risk Morbidities

Vishal Chavda1, Bipin Chaurasia2, Alessandro Fiorindi3

  • 1Department of Pathology, Stanford School of Medicine, Stanford University Medical Center, San Francisco, CA 94305, USA.

Neurology International
|June 1, 2022
PubMed

Insights

COVID-19 and stroke share complex pathophysiology and risk factors, making them a dangerous combination. Understanding these links is crucial for effective medical management and developing new COVID-19 stroke therapeutics.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Science

Background:

  • Stroke is a critical condition requiring immediate medical care.
  • COVID-19 presents neurological symptoms, including ischemic brain damage, complicating treatment.
  • Co-morbidities like diabetes and hypertension exacerbate risks in COVID-19 patients.

Purpose of the Study:

  • To review the literature on COVID-19 and stroke.
  • To explore shared pathophysiology and risk factors between SARS-CoV-2 infection and stroke.
  • To discuss challenges and advancements in managing stroke-associated COVID-19.

Main Methods:

  • Literature research was conducted using PubMed, MEDLINE, and Scopus.
  • A narrative review approach was employed.
  • Analysis focused on published papers detailing COVID-19 and stroke.

Main Results:

  • SARS-CoV-2 infection and stroke exhibit parallel manifestations and risk factors.
  • The pathophysiology of COVID-19 and stroke shows complex similarities.
  • COVID-19 combined with co-morbidities presents a fatal risk in intensive care.

Conclusions:

  • COVID-19 and stroke represent a lethal combination due to shared risk factors and pathophysiology.
  • Effective medical management requires addressing these intertwined conditions.
  • Further research into therapeutics for stroke-associated COVID-19 is essential.

Keywords:
COVID-19SARS-CoV-2anti-coagulantsischemianeurologyneurosurgerystroketherapeutics

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