Toxicity of n-hexane and 2,5-hexanediol to the haemopoietic system: a preliminary report

The effect of n-hexane and its metabolite, 2,5-hexanediol, on the haemopoietic system has been investigated in the rat. 59Fe uptake was decreased in the bone marrow of n-hexane-treated animals. Spleen and bone marrow were the target sites for the metabolite 2,5-hexanediol, whereas n-hexane as such does not affect these organs.