Related Experiment Video
Updated: Sep 21, 2025
13:47
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
9.4K
Metabolomics in Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis
Yizhen Tang1,2, Simran Shah2, Kin-Sang Cho2
1Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Frontiers in Neuroscience
|June 1, 2022
Summary
Primary open angle glaucoma (POAG) may involve metabolic changes. This meta-analysis identified specific metabolites altered in POAG patients, offering potential biomarkers for early detection and new research avenues.
Area of Science:
- Ophthalmology and Metabolic Research
Background:
- Glaucoma is a leading cause of global blindness.
- Primary open angle glaucoma (POAG), the most prevalent form, is suspected to involve metabolic alterations.
- A comprehensive review and meta-analysis of POAG metabolomics has been lacking.
Approach:
- A systematic meta-analysis was conducted on existing literature.
- The analysis focused on metabolomic profiles in patients with POAG.
- Identified metabolites associated with the disease were examined.
Key Points:
- Metabolomic profiles in aqueous humor and plasma may indicate potential biomarkers.
- Specific metabolites were found to be significantly altered in POAG patients.
- These findings suggest broad generalizability and potential research pathways.
Conclusions:
- Metabolomic alterations are associated with primary open angle glaucoma.
- Identified metabolites could serve as early detection biomarkers or therapeutic targets.
- Further research into POAG metabolomics is warranted.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
619
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
619
01:25Glaucoma: Overview
815
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
815
01:28Angle Closure Glaucoma: Treatment
746
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
746