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Updated: Sep 21, 2025

Modulation of the Neurophysiological Response to Fearful and Stressful Stimuli Through Repetitive Religious Chanting
Published on: November 4, 2021
Islamic praying changes stress-related hormones and genes
Vahid Sobhani1, Ehsan Manshadi Mokari2, Jafar Aghajani3
1Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Islamic prayer (Namaz) impacts stress hormones and gene expression. Namaz significantly altered cortisol levels and decreased BDNF gene expression in healthy adults, suggesting potential stress-reduction benefits.
Area of Science:
- Psychoneuroendocrinology
- Molecular Biology
- Religious Studies
Background:
- Islamic prayer (Namaz) integrates mental, spiritual, and physical elements.
- Stress-related hormones and gene expression play crucial roles in health and well-being.
- Understanding the physiological effects of religious practices like Namaz is an emerging area of research.
Purpose of the Study:
- To investigate the immediate physiological effects of Namaz on stress markers.
- To examine the impact of Namaz on cortisol and alpha-amylase hormone levels.
- To evaluate the influence of Namaz on the expression of stress-related genes, specifically IL6 and BDNF.
Main Methods:
- Eighty-three healthy adult Namaz practitioners provided saliva samples before and after prayer.
- Cortisol and alpha-amylase levels were measured in saliva samples.
- Gene expression analysis for BDNF and IL6 was performed on a subset of 11 participants.
- Participants were stratified into groups based on baseline cortisol levels.
Main Results:
- Cortisol levels showed a significant increase in the low baseline group and a decrease in the high baseline group post-Namaz.
- Alpha-amylase levels increased in participants with low baseline concentrations.
- A significant reduction in Brain-Derived Neurotrophic Factor (BDNF) gene expression was observed after Namaz.
- Hormonal changes (cortisol and alpha-amylase) moved towards optimal ranges following Namaz.
Conclusions:
- Namaz appears to have an immediate, measurable impact on physiological stress markers.
- The practice may modulate stress hormone levels and reduce the expression of BDNF.
- These preliminary findings suggest Namaz could be a beneficial practice for stress management, warranting further investigation.
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