Related Experiment Video
Updated: Sep 21, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
Ling-Yu Chu1, Bin-Liang Huang2, Xu-Chun Huang2
1Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, Guangdong Province, China.
Abstract:
Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors. The role of EFNA1 in tumorigenesis and development is complex and depends on the cell type and microenvironment which in turn affect the expression of EFNA1. This article reviews the expression, prognostic value, regulation and clinical significance of EFNA1 in gastrointestinal tumors.
Related Concept Videos
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Mitogens and the Cell Cycle
Regulation of Angiogenesis and Blood Supply
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

