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Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism

Angela Vidal1, Carolin Dhakal1

  • 1Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Switzerland.

Case Reports in Obstetrics and Gynecology
|June 1, 2022
PubMed

Thalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload-haemosiderosis-can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency.

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