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Updated: Sep 21, 2025

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
Not all lytic bone lesions are malignant: A report of syphilitic osteitis presenting with multiple lytic skull
Ahmad Rajeh1, Mohammed Saleh1, Ademola S Ojo2
1Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Abstract:
Syphilitic osteitis is one of the rare and often under-reported complications of early syphilis. Recognizing this entity is important as it may mimic other conditions like multiple myeloma, lymphoma, or metastatic malignancies. Misdiagnosis and delayed management can lead to irreversible destructive lesions. We herein report a case of calvaria syphilitic osteitis that was initially investigated for possible lymphoma and later diagnosed as secondary syphilis.
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