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Infant prostatic Rhabdomyosarcoma: A diagnostic and therapeutic challenge
Sohail Dhanji1, Leonardo D Borregales1, Nicolette K Janzen2
1The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, United States.
Insights
This case report details a rare prostatic rhabdomyosarcoma in an infant, presenting with urinary issues. Treatment involved chemotherapy and surgery due to tumor progression.
Area of Science:
- Pediatric Oncology
- Urologic Pathology
Background:
- Rhabdomyosarcoma is a rare malignancy in infants.
- Prostatic involvement is exceptionally uncommon.
Observation:
- A 6-month-old male presented with urinary retention and constipation.
- MRI revealed a prostatic mass causing bladder outlet obstruction.
Findings:
- Biopsy confirmed prostatic rhabdomyosarcoma.
- The patient received VAC chemotherapy, then ifosfamide and doxorubicin.
- Tumor progression necessitated radical cystoprostatectomy and ileal conduit.
Implications:
- This case highlights the importance of considering rare diagnoses in pediatric urologic emergencies.
- Multimodal treatment is crucial for managing advanced prostatic rhabdomyosarcoma.
- Surgical intervention may be required for refractory cases.
Abstract:
The following case report describes a case of prostatic rhabdomyosarcoma in a 6-month-old male who presented with urinary retention and constipation. MRI showed a prostatic mass that was displacing the rectum and bladder, leading to bladder outlet obstruction. A suprapubic tube was placed for urinary diversion and a transvesical approach was used for tissue diagnosis. Biopsy confirmed the diagnosis of prostatic rhabdomyosarcoma. Patient underwent chemotherapy regiment with VAC (vincristine, actinomycin D and cyclophosphamide) and subsequently ifosfamide and doxorubicin. Eventually, due to tumor progression, the patient underwent a radical cystoprostatectomy with pelvic lymph node dissection and ileal conduit.
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