Related Experiment Video
Updated: Sep 21, 2025
11:13
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
1.7K
Research Advances on Anti-Cancer Natural Products
Meng Guo1, Jie Jin1, Dong Zhao2
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Frontiers in Oncology
|June 1, 2022
Summary
Natural products show promising anti-cancer activity and are classified into eight groups. This review details their latest advances, molecular mechanisms, and derivatization for developing new cancer drugs.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Oncology
Background:
- Malignant tumors pose a significant global health threat.
- Natural products offer advantages over traditional chemotherapy due to known structures and pharmacological effects.
- Certain natural products demonstrate notable anti-cancer properties.
Purpose of the Study:
- To review recent advancements in the anti-cancer activity of natural products across eight chemical classes.
- To summarize the molecular mechanisms underlying the anti-cancer effects of these compounds.
- To explore the derivatization of natural products for novel anti-cancer drug development.
Main Methods:
- Systematic review of literature on natural products and their anti-cancer activities.
- Classification of natural products into eight categories based on chemical structure.
- Detailed summary of anti-cancer molecular mechanisms and derivatization strategies.
Main Results:
- Natural products, including alkaloids, terpenoids, flavonoids, and polysaccharides, exhibit significant anti-cancer potential.
- Various molecular mechanisms contribute to the anti-cancer effects of natural products.
- Derivatization offers a pathway to enhance the efficacy and develop novel anti-cancer agents.
Conclusions:
- Natural products represent a valuable resource for anti-cancer drug discovery.
- Understanding their molecular mechanisms and chemical modifications is crucial for future development.
- This review provides insights and potential core structures for new anti-cancer therapies.
More Related Videos
09:03Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
478
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.6K
Related Concept Videos
02:59Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
01:21Cancer Survival Analysis
463
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
463
02:49Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
01:15Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K